I doubt you'd notice any mis-alignment as long as the wheels are parallel. As for chainline - it really won't make a difference either. (reality). As the newer chains will have plenty of lateral tolerance to accommodate any chainline angle. In other words - don't sweat it . If you don't like scrunching in your stays - then just toss in a couple washers. In fact - the space is more on the NDS then the DS, btw. So - you're correct in placing your 'thick washer' on the NDS. Trust me - I run this similar combination all the time on my Toge Warrior which is set for 130mm (fixed gear) but I run 3 different rear wheels with no issues! 120mm Track, 130mm Fixed and 135mm Alfine. The only difference is a few cheap washers on the NDS. The frame IS titanium which is very 'memory' oriented - but it's similar to Cromo in its tolerance for this kind of abuse.